In Domos characters go out on missions which are based on rumors. These rumors are gathered during missions, said by NPC’s in RP or made up by the players themselves. Each session has a different party and a different DM. You can find out more about how missions work in how to adventure.
A quick guide to adventuring in Domos:
There are no set game days; sessions are discussed and planned in #adventure-planning.
There are no set party compositions, there is no gaurantee you'll be playing with the exact same group twice.
There are no plothooks that lead to railroads, there are solely story points that may contain failstates.
The players explore the world on their own accord. Teamwork is necessary.
Communication is key, the GMs and players are telling a grand story together.
You are not allowed to play more than two games a week. This to make sure there is room for everyone to play. This is excluding event-based sessions.
Below you'll find a Quick reference sheet for Pf2e Combat actions.

It is recommended to download this image and/or have it open during sessions.
Credits to: PhoebusDF on reddit.
Domos also includes a 24/7 text RP, where characters can chat and hang out in their downtime. This is not the main focus of Domos and a player can decide for themselves if they would like to participate or not. You can find out more about roleplay in Domos and it's rules in the the roleplay page.
Downtime can be used in several ways:
Earning income
Crafting
Retraining your character.
There is much a character can do during downtime. Since we are playing with a large group, there is also a large amount of downtime. To balance this, downtime is treated as a resource in Domos. Learn more about gaining and using downtime.
Trading items is fairly simple. Since you have a shop available at all times, there are no limits to how many times you can go shopping. To learn more about item management read the How to buy, sell, lend and trade page.